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6 Wonderful Terpenes For Wellness

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6 Wonderful Terpenes For Wellness

Terpenes are a large and diverse class of aromatic organic compounds that are found in the essential oils of plants.

The integral role of terpenes in medical cannabis research has led to increased interest and recognition of the potential holistic benefits of these compounds in recent years.

The unique scents from these compounds are not only distinctive, but also functional, protecting plants from predators and environmental stressors.

Terpenes Are Everywhere
Terpenes are produced by many species of plants and even some insects. Conifers (e.g. pine trees) for instance, contain high levels of a-Pinene while citrus usually contains high levels of Limonene.

Wine connoisseurs are also known to discuss terpenes as there are over 50 terpene compounds, including Linalool that have been identified in grapes and wine.


The Most Common Terpenes
In cannabis plants, there are over 200 known terpenes, and they are the reason why every strain has a unique smell and different effects.

Some of the most interesting and prevalent cannabis terpenes from a wellness perspective are briefly described below.

  • Myrcene, which is also found in mangoes is the most prevalent terpene found in cannabis, especially indica-dominant strains and it is known to promote a sedative, relaxing effect. β-myrcene is also unique in that it crosses the blood-brain barrier, increasing potency and rapid onset of cannabinoids and synergistic terpene action.
  • Beta Caryophyllene is another terpene with unique properties as it is the only non-cannabinoid plant molecule that interacts with the human endocannabinoid system (ECS), illustrating the impact of terpenes on the therapeutic effects of cannabinoids.
    β–caryophyllene binds to the CB2 receptor found in the central and peripheral nervous system, and is thought to play a major role in managing inflammation [1].Caryophyllene is prevalent in cannabis plants as well as black pepper, cloves and cinnamon among other species.
  • Pinene has an aroma of pine and firs, with both α-pinene and β-pinene being primary constituents of pine resin. Often used to treat inflammation, α-pinene is the most commonly found terpene throughout nature.
  • Linalool has been isolated from more than 300 different plants and has aromatic undertones of floral and lavender. Users often report calming relaxing effects and it has been used for centuries as a sleep aid. Linalool is also a precursor critical to the production of Vitamin E in plants.
  • Limonene is the primary constituent of fruit rinds, as well peppermint, juniper, rosemary and many pine needle oils. This terpene with it’s citrusy, lemon orange aroma is reported to produce uplifting and mood enhancing effects in users. Limonene is also a natural insecticide to protect plants from predators.
  • Humulene is found in cloves, basil and hops and has an earthy aroma that gives beer its distinctive “hoppy” aroma. One of the distinctive attributes of Humulene is its reported appetite suppression effect. Humulene has been widely used for more than 1,000 years in Chinese medicine.

Entourage Effect
In addition to their own individual holistic effects, terpenes work synergistically with one another as well as cannabinoids like CBD to increase therapeutic potential, modulate efficacy and mitigate unwanted effects, a phenomenon referred to as the “Entourage Effect”.

Potential Holistic Benefits
When choosing CBD oil products, terpenes potentially offer a significant improvement in the overall experience for end-users.

Research On Terpenes
More research is need to understand the individual effects of terpenes and their synergistic interactions with cannabinoids and other compounds, but the early results are very encouraging for the future of terpene exploration!

 

 

 

[1] Russo https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165946/

[2] Bonamin http://www.aromaticscience.com/the-effect-of-a-minor-constituent-of-essential-oil-from-citrus-aurantium-the-role-of-%CE%B2-myrcene-in-preventing-peptic-ulcer-disease/

3 Cannabinoids To Consider For Your Health

By | Cannabinoids, CBD, Endocannabinoid System | No Comments

3 Cannabinoids To Consider For Your Health

When it comes to cannabinoids, many people are familiar with the two most commonly known molecules, THC and CBD (and their respective variants).

CannabinoidsWhat many people don’t know however is that these molecules have many counterparts within the hemp and cannabis plant genealogy.

There are currently a minimum of 113 known cannabinoids that have been identified through research and independent studies.

Research has revealed that the human endocannabinoid system (ECS) regulates homeostasis within the human body and these plant based molecules (phyto-cannabinoids) interact with the ECS and endogenous cannabinoids to deliver the myriad health benefits that have been reported by users and confirmed in numerous studies.


Below you will find a brief summary of 3 cannabinoids getting more attention recently for their potential holistic properties and health benefits.

CBN – Cannabinol

Cannabinol, or CBN may sound very similar to it’s relative Cannabidiol (CBD) but CBN displays its own unique array of medical benefits and effects that have researchers anxious to continue investigating this molecule.

Some of the benefits already discovered include:

  • Pain relief [1]
  • Anti-insomnia [2]
  • Promotes growth of bone cells
  • Antibacterial [3]
  • Anti-inflammatory [4]
  • Anti-convulsive
  • Appetite stimulant [5]

One of CBN’s most interesting and noteworthy attributes is the sedative effect it has on users. According to a study by Steep Hill Labs, 5mg of CBN is as effective as a 10mg dose of the pharmaceutical sedative diazepam.

CBN does not induce a psychoactive effect and has shown no negative side effects.

CBC – Cannabichromene

Cannabichromene is another lesser known cannabinoid that has some amazing potential medical benefits for users.

Recent studies have suggested that CBC may contribute to the overall analgesic effects of medical cannabis.

Here of some of the most noteworthy findings so far about CBC:

  • Promotes Neurogenesis (Brain Growth) [6]
  • Antidepressant [7]
  • Anti-inflammatory [8]
  • Pain relief [9]
  • Antibacterial and antifungal [10]

CBC has been found to interact with many receptors in the brain. While it is common for most cannabinoids to interact with the CB1 and CB2 receptors, CBD interacts with other receptors as well.

CBC in particular is known to interact with the TRPV1 and TRPA1 receptors as well, which may result in some of its medicinal properties.[6]

CBG – Cannabigerol

CBG is a cannabinoid that is known as the building block for many compounds in cannabis, including THC and CBD.

CBG is non-psychoactive and can be thought of as the “stem cell” or “parent” of other cannabinoids. However, CBG is not found in high concentrations in most strains. Certain strains of hemp may have higher CBG content.

CBG is important because of its numerous health benefits, especially for people with disorders affecting the central nervous system, including neurological diseases, skin disorders, chronic pain, and others.

The medical benefits of CBG are still under investigation, but the list thus far is impressive and growing.

  • Stimulates bone formation and healing [11]
  • Slows tumor growth [12]
  • Antifungal and antibacterial treatment. [13]
  • Relieves pain [14]
  • Reduces inflammation [15]
  • Overactive bladder treatment  [16]
  • Psoriasis and skin treatment.  [17]
  • Glaucoma treatment. [18]
  • Depression and anxiety treatment [19]
  • Neuroprotective effects. [20]

CBG can also affect the body by increasing anandamide levels. Anandamide is a naturally-occurring cannabinoid that helps regulate many biological functions, including appetite, sleep and memory.

The effect of CBG on GABA (gamma aminobutyric acid – a brain chemical that regulates the activity of neurons) uptake was found to be greater than both THC and CBD in one study.

CBG has been shown to block serotonin receptors as well, which suggests a role for CBG in treating depression.

It’s important to note that much of the evidence comes from pre-clinical studies, meaning that the safety and efficacy of most cannabinoids has yet to be proven in humans. That being said, studies on CBN, CBC and CBG have revealed a wide range of possible benefits.

HealthSmart CBD offers full-spectrum hemp oil CBD products that include all three of the amazing cannabinoids and a more comprehensive array of medical cannabinoids than you can find anywhere in any other product.

Study: CBD Reduces Cigarette Consumption By 40%

By | CBD, CBD Research, CBD Vape, Vaporization | No Comments

New study finds CBD can reduce cigarette consumption in tobacco users by 40% in just one week of treatment.

If you are a smoker you have surely heard the all of the statistics by now, but just in case you need a reminder – here are some staggering numbers to consider…

  • Cigarette smoke contains over 4,000 chemicals, including more than 250 known to harm humans.
  • Smoking cigarettes kill more people each year than HIV, illegal drug use, alcohol use, motor vehicle accidents and gun-related incidents combined.
  • 1 out of every 5 deaths in the US is from tobacco.
  • One  person dies every six seconds from tobacco. (That’s 10 People per minute).

Despite the alarming statistics many people find it difficult or impossible to quit tobacco because of an addiction to nicotine.

This is a common condition as nicotine is one of the most addictive substances on the planet and quitting can be a physically and mentally challenging battle for many smokers.

Smoking Vs. Vaping

A lot of ex-smokers have quit smoking cigarettes recently with the advent of vaporizer technology allowing them to avoid the dangers of burning tobacco without completely quitting nicotine.

Unfortunately, these vape pens and devices typically contain “e-juice” that includes nicotine, often in even greater amounts than cigarettes.

On top of the nicotine issue, the vaporizers that create the large clouds of smoke that some users enjoy, also raise a lot of potential risks and health concerns of their own.

It will be years before there is enough definitive evidence to know if vaping nicotine is actually safer or healthier than smoking cigarettes, but it is definitely more convenient and discreet for many users.

Recently, an exciting new alternative has shown tremendous potential to help smokers who want to quit using tobacco and nicotine altogether.

Study: Cannabis Compound Reduces Cigarette Consumption

The scientific journal Addictive Behaviors recently published clinical trial data containing preliminary results showing that inhalation of the non-psychoactive cannabinoid CBD (cannabidiol) significantly mitigates tobacco smokers’ desire for cigarettes.

In the study, 24 cigarette smokers were recruited and split into two groups, receiving inhalers containing CBD or placebo.

Both groups were told to use the inhalers whenever they felt the urge to smoke during a one week period.

Researchers found: “Over the treatment week, placebo treated smokers showed no differences in number of cigarettes smoked. In contrast, those treated with CBD significantly reduced the number of cigarettes smoked by [the equivalent of] 40 percent during treatment.”

Moreover, participants who used CBD did not report experiencing increased cravings for nicotine during the study’s duration.

“This is the first study, as far as we are aware, to demonstrate the impact of CBD on cigarette smoking. These preliminary data, combined with the strong preclinical rationale for use of this compound, suggest CBD to be a potential treatment for nicotine addiction that warrants further exploration.”

The Most Effective Way To Consume CBD

Most people are unaware that the method by which you choose to ingest CBD can dramatically affect the effective dosage you receive.

In general, only a certain percentage of the cannabidiol you consume will be able to enter your system to produce it’s active effects. This is commonly referred to as “bioavailability”.

When consumed orally, the typical bioavailability of CBD is roughly 15 percent of the total milligrams consumed.

Because CBD is hydrophobic, meaning that it is not very water-soluble, it does not like to stay in the bloodstream, accumulating in fatty tissues instead. This reduces bioavailability.

The digestive process known as “first-pass effect” also reduces the concentration of bioactive compounds that can enter the bloodstream after passing through your liver.

The most effective way to offset this loss of bioavailability is to avoid the first-pass effect completely and ingest CBD through vaporization.

When inhaling CBD from a vaporizer cartridge or CBD vape pen, the substance enters through your lungs and diffuses into your your bloodstream directly, bypassing the liver and gut.

This increases amount of CBD in your bloodstream by roughly 400% versus oral consumption to achieve maximum bioavailability of up to 60% of the dosage you consume. This means you can achieve the same beneficial effects with a much smaller amount of cannabidiol.

In addition to the increased bioavailability, vaporization also delivers a much faster onset of effects since it does not have to travel through your digestive system. When vaporizing CBD, the effects can become active within a matter of seconds, compared with typical 30 to 60 minute onset when consumed orally.

When considering all of these factors, vaporization is clearly the most efficient and cost effective way to consume CBD. When used on a regular basis to mitigate the cravings associated with nicotine addiction, research indicates CBD inhalation offers promising potential for helping people to quit smoking tobacco.

A Healthy CBD Vape Alternative

HealthSmart CBD offers a line of CBD vape pens and disposable CBD vape cartridges that contain 100% organic ingredients. Without any additives or fillers commonly found in e-juice or vape products like PG (propylene glycol), PEG (polyethylene glycol), VG (vegetable glycerin) or MCT oil, these CBD products are a more health conscious alternative to other means of vaporization. HealthSmart CBD Vape Cartridges contain only CBD concentrate and natural terpenes.

Click here to Shop HealthSmart CBD Vape Cartridges now available in 3 varieties: Awake, Calm and Relax.

 

References:

https://www.ncbi.nlm.nih.gov/pubmed/23685330

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444130/

https://www.cdc.gov/tobacco/data_statistics/fact_sheets/health_effects/effects_cig_smoking/

FDA Declares CBD ‘Beneficial,’ Wants Your Input ASAP

By | Cannabis Laws, CBD, CBD Oil, PolItics | No Comments

FDA Declares CBD ‘Beneficial,’ Wants Your Input ASAP

The United Nations is trying to figure out how to categorize cannabidiol(CBD), a non-psychoactive and medically beneficial cannabinoid contained in cannabis. And UN officials, through the US Food and Drug Administration (FDA), are asking for your help.

The FDA declared that ‘CBD has been shown to be beneficial.’ Now the agency needs your comments to back it up.

FDA officials put out a call for comments in this morning’s Federal Register, seeking information about CBD and how the UN’s World Health Organization (WHO) should designate it under the 1971 Convention on Psychotropic Substances. In doing so, the FDA acknowledged the ‘beneficial’ effects CBD has shown in patients with neurological disorders.

All those who have information on, or experience with, the use of CBD as a healing substance are encouraged to comment at this federal website. Sept. 13 is the deadline for public comment, and no input will be considered after that date.

 

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The CBD Entourage Effect & Pain Management

By | CBD Oil, Endocannabinoid System, Hemp Oil, Medical Cannabis, Pain Relief | No Comments

THE CBD ENTOURAGE EFFECT & PAIN MANAGEMENT

Chronic pain is a public health issue of massive proportions, with more than 100 million Americans and more than 1.5 billion people globally suffering from pain lasting more than 24 hours.

In fact, chronic pain affects more Americans than diabetes, heart disease and cancer combined.

The Cost Of Pain In America

As a society, the cost of pain is estimated in recent studies published by the Institute of Medicine to be “at least $560-$635 billion annually, an amount equal to about $2,000.00 for everyone living in the U.S.

Prescription painkillers have only made the problem much worse.

According to an article on CNN Health, “every day, 91 Americans die from an opioid overdose.”

“Drug overdoses overall — most of them from opioid painkillers and heroin — are the leading cause of accidental death in the US, killing more people than guns or car accidents.

In fact, while Americans represent only about 5% of the global population, they consume about 80% of the world’s opioid painkillers.<

New Discoveries With Ancient Roots

Cannabis has been used for more than twelve thousand years and for many different purposes (i.e. fiber, medicinal, recreational).

“The ability of extracts of the hemp plant (Cannabis sativa) to cause a variety of medicinal effects unrelated to its psychoactive properties had been recognized as early as the third millennium BC, when Chinese texts described its usefulness in the relief of pain and cramps (Mechoulam, 1986).”

“In ancient India, the anxiety-relieving effect of bhang (the Indian term for marijuana ingested as food) had been recorded more than 3000 years ago.”

 

During the 19th Century “cannabis extracts gained widespread use for medicinal purposes until 1937” when marijuana was banned by the US Federal Government.

With overwhelming public support and more states legalizing recreational and/or medical marijuana, cannabis has once again “recently been the focus of medical research and considered a potential therapeutic target [13].“

Endocannabinoids Regulate Analgesia & Inflammation

Groundbreaking discoveries about the “endocannabinoid system” or ECS and the potential implications of the “Entourage Effect” for pain mitigation without side effects are one of the most significant developments in medical neuroscience as it relates to human homeostasis and pain management.

According to the U.S. Department Of Health & Human Services (HHS), “the therapeutic potential of cannabinoids has been the topic of extensive investigation following the discovery of cannabinoid receptors and their endogenous ligands which are present at supraspinal, spinal and peripheral levels.

More significantly for the purposes of the present review, they are found at central and peripheral levels of the pain pathways [2832].”

Endocannabinoid receptors are in fact the most abundant receptors in the mammalian brain and are also found throughout the peripheral central nervous system and in muscles, bones, tissues and organs.

According to HHS, these receptors or “endocannabinoids” are “the brain’s own cannabis-like substances which serve as synaptic circuit breakers and regulate multiple physiological and pathological conditions including food intake regulation, immunomodulation, inflammation, analgesia (pain), cancer, addictive behavior, epilepsy and others.

Since the relatively recent discovery of endocannabinoids through the study of medical cannabis, the entire natural complex came to be called the “endogenous cannabinoid system,” or “endocannabinoid system” (ECS).

Topical Application of Cannabidiol (CBD)

Considering the fact that there are cannabinoid receptors throughout the peripheral CNS, it only makes sense that applying cannabinoids directly to the affected area with a salve, gel or balm would have therapeutic benefits.

This therapeutic benefit has been confirmed by clinical research published by the NIH National Library of Medicine: “These studies demonstrate transdermal administration of CBD has long-lasting therapeutic effects without psychoactive side-effects.”

Topical application of CBD has even shown great potential in these same studies as a treatment for chronic pain issues such as arthritis: “Topical CBD application has therapeutic potential for relief of arthritis pain-related behaviours and inflammation without evident side-effects.”

“Thus, use of topical CBD has potential as effective treatment of arthritic symptomatology. At present, one in five (21%) adults worldwide are diagnosed with some form of arthritis by their physicians (Helmick et al., 2008). The data presented suggest transdermal CBD is a good candidate for developing improved therapies for these debilitating disease.”

“Transdermal CBD gel significantly reduced joint swelling, limb posture scores as a rating of spontaneous pain, immune cell infiltration and thickening of the synovial membrane in a dose-dependent manner. “

“These studies suggest that manipulation of peripheral endocannabinoids may be promising strategy for the management of pain.”

Normalized Sleep With CBD Helps Pain

According to the US Department of Health & Human Services, National Institute of Health “Cannabinoids may have another therapeutic benefit in managing chronic pain, with regard to sleep. –  It has been reported that cannabinoids suppress sleep-related apnea.”

Opioid painkillers can also lead to more serious problems when taken in conjunction with other medications, especially benzodiazepines like Xanax.

Not only does normalized sleep improve pain relief and mood disorders associated with both poor pain control and poor sleep patterns, but there is significant risk of sleep-disordered breathing associated with central nervous system (CNS) drugs used to treat chronic pain.111

“Opioid analgesics are most problematic, especially if combined with other CNS depressants such as benzodiazepines. “

Improving Efficacy With Adjunctive Therapies

These studies also indicate that when intractable pain requires the use of opioid painkillers, cannabinoid treatment can be effectively used as an adjunctive treatment to improve the efficacy of the opioids while limiting the negative side effects.

“Adjunctive approaches show strong promise for improving the efficacy of existing pharmacotherapies for pain and limiting unwanted side-effect profiles.”

A Mountain Of Evidence

The scientific evidence supporting the efficacy of cannabinoids to regulate pain is overwhelming and backed by more than a decade of research.

Reports published by the U.S. National Institutes of Health’s National Library of Medicine find thatEndocannabinoids modulate pain under physiological conditions. and “Cannabidiol (CBD) attenuates inflammation and pain without side-effects.”

CBD and other plant derived cannabinoids have unlimited potential for new treatment options to help people with neuropathic and chronic pain conditions.

The phytocannabinoids have efficacy in the treatment of various chronic pain conditions with greatest promise as a therapeutic adjunct in treating peripheral and central neuropathic pain and inflammation-mediated chronic pain.

In addition to chronic pain relief, cannabinoids have also shown efficacy in treatment of acute pain as well.

“Exogenous administration of endocannabinoids or their modulation via inhibition of endocannabinoid deactivation or uptake can produce antinociception in acute pain models.”

The Entourage Effect – Cannabinoid/Terpene Synergy

Research has revealed that the holistic benefit and therapeutic results of cannabinoid related treatments can be greatly improved by “Entourage Effect” derived from nature’s divine integration of unique blends of terpenes and cannabinoids in cannabis plants.

According to the US National Institute of Health “A chemical class known as the terpenes shares a precursor molecule with phytocannabinoids; they are all flavor and fragrance components common to human diets.

Terpenes have been designated “generally recognized as safe” (GRAS) by the US Food and Drug Administration and other regulatory agencies.

The entourage effect is the term used to describe enhancement of efficacy, with related improvement in overall therapeutic effectiveness, derived from combining phytocannabinoids and other plant-derived molecules.

Common cannabis-derived terpenes include limonene, myrcene, α-pinene, linalool, β-caryophyllene, caryophyllene oxide, nerolidol, and phytol.105 These terpenes are also found in many other plants.

Terpenes are quite potent and affect animal and even human behavior when inhaled in very low concentrations.

They display unique therapeutic effects that may contribute meaningfully to the entourage effects of Cannabis-based medicinal extracts.

Of particular interest are the phytocannabinoid–terpene interactions that could produce synergy with respect to treatment of pain and inflammation.

Phytocannabinoid–terpene synergy increases the likelihood that an extensive pipeline of new therapeutic products is possible from this age-old plant.

The terpene β-caryophyllene is found in a number of commonly available plants, including black pepper, cinnamon, clove, and other spices.  It selectively binds to the CB2 receptor at nanomolar concentrations and acts as a full agonist.

“β-Caryophyllene and cannabidiol occur abundantly in Cannabis sativa.

“So this plant species produces at least two entirely different chemical substances able to target CB2 receptors differentially.”

“While studies on the pharmacokinetics of β-caryophyllene are still on-going, it is already clear that this terpene is readily bioavailable.“

“Orally administered β-caryophyllene (<5 mg·kg−1) produces strong anti-inflammatory and analgesic effects”107

“On-going studies show that β-caryophyllene is effective at reducing neuropathic pain in a CB2 receptor-dependent manner.”108

Like other CB2 ligands β-caryophyllene inhibits the pathways – of pro-inflammatory cytokines and promotes a Th1 immune response that plays a critical role in neuroinflammation, sensitization, and pain.109

Therefore, the FDA-approved food additive β-caryophyllene seems an attractive candidate for clinical trials targeting the CB2 receptor.

The NIH Studies also state that if using an opioid pain-killer for intractable pain, the use of non-psychoactive cannabinoids like CBD may offset some of of the undesirable side-effects of the opioids, while obtaining far greater analgesic results.

Indeed, in cases of intractable or difficult-to-control pain, combination therapy with small doses of opioid and non-psychoactive cannabinoid receptor agonists may be an alternative way to circumvent the undesirable side effects of opioids yet obtain far greater analgesic efficacy than achieved with cannabinoids alone.56,110

Conclusion – A Powerful Entourage For Pain Management

Nature’s divine synergy of plant Terpenes and Cannabinoids have worked together for thousands of years to form a powerful entourage of holistic healing and now science has backed it up with real data.

Putting these pharmacologic, clinical, and societal issues together, the direction for the future resides in the development of orally administered, highly bioavailable, non-psychoactive phytocannabinoid products that also take advantage of the entourage effect, to provide the millions of people living with debilitating pain a comparatively safe and effective form of relief.

 

The science of cannabinoids and terpene synergy is continuing to expand rapidly, but decades of research have led to a clear conclusion from the U.S. National institute of Health that endocannabinoids play a critical role in pain management.

We also know that exogenous cannabinoids offer a safe and effective alternative for pain relief and that is good news for the millions of people around the world suffering from chronic pain.

 

Resources:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2241751/

https://www.ncbi.nlm.nih.gov/pubmed/19675519

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820295/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3997295/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2834283/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2503660/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202504/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3728280/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4851925/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828614/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048583/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2834283/

Studies: Cannabis Proven To Effectively Treat Neuropathic Pain

By | CBD Oil, Medical Cannabis, Pain Relief | No Comments

Cannabis Proven To Effectively Treat Neuropathic Pain

Researchers at the University of Glasgow have published findings that confirm what so many users of medical cannabis already know: Cannabis oil helps with neuropathic pain.

In a double blind, placebo controlled, parallel group study of THC/CBD oil in peripheral neuropathic pain treatment “there were statistically significant treatment differences in favour of THC/CBD spray in the full analysis (intention-to-treat) dataset”

“These findings demonstrate that, in a meaningful proportion of otherwise treatment- resistant patients, clinically important improvements in pain, sleep quality and SGIC (Subject Global Impression of Change) of the severity of their condition are obtained with THC/CBD spray,” the researchers concluded. “THC/CBD spray was well tolerated and no new safety concerns were identified.”

Chronic pain is a public health issue of massive proportions, particularly in aging populations. Typical treatment options for neuropathic pain have limited efficacy and use is fraught with dose-limiting adverse effects.

For several years intensive research has been conducted into the human endocannabinoid system and its role in homeostasis – the body’s internal equilibrium. Some of the most intriguing findings relate to the endocannabinoid system and pain management.

In addition to the University of Glasgow report, numerous published studies have found that  “cannabinoids have been proven to be effective” and there is “mounting evidence for therapeutic use in human neuropathic pain conditions”.

Cannabis has been proven to help with neuropathic pain associated with other health issues as well. More than 10 years of research show consistent findings related to cannabinoids and pain relief:

While many earlier studies focused on the pain relieving properties of THC, we are now learning that the cannabinoid CBD plays just as large a role in the treatment of pain as THC.

The continuously growing number of studies and anecdotal accounts of people who get relief from peripheral neuropathy by using cannabis — whether by smoking, vaporizing, ingesting, or using an oral spray like in the University of Glasgow study — suggests that cannabis and its main ingredients can play a major role in pain management.

Always do your own research and find the solution that is right for your particular situation, but if you are suffering from neuropathic or chronic pain, the evidence suggests that you should consider looking into CBD as a viable alternative.

9 Remarkable Healing Properties Of CBD

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9 Remarkable Healing Properties Of CBD

Cannabis is known to have 85+ different cannabinoids, many of them potentially having health benefits.

“Cannabinoids promote homeostasis at every level of biological life, from the sub-cellular to the organism, and perhaps to the community and beyond,” writes NORML, a foundation that works to reform marijuana laws.

According to research, cannabinoids synergize and help support humans’ built-in Endocannabinoid System (ECS). It was in 1992 that scientists discovered that the ECS plays a direct role in homeostasis, which regulates every metabolic process in the body, such as pain sensation, appetite, temperature regulation, stress reactivity, immune function, and sleep, as well as other processes. Even more interesting is that muscle and fat tissue also utilize these receptors to control their processes.

So basically, CBD communicates with our body’s main command center to keep things running as they should. Pretty amazing.

 

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U.S. CBD Sales Projected to Reach $2.1B by 2020

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New Report: U.S. CBD Sales to Reach $2.1B by 2020 With $450M From Hemp Industry

The Hemp Business Journal (HBJ), the hemp industry’s authority on big data and market intelligence, has released The CBD Report showing cannabidiol as one of the fastest growing market categories in the U.S. hemp and legal marijuana industries with a compound annual growth rate of 59%.

Partnering with market leading consumer data experts SPINS and BDS Analytics, market modeling experts and hemp insiders with years of experience and sales data, Hemp Business Journal estimates the total U.S. CBD market will grow to a $2.1 Billion market in consumer sales by 2020 with $450 million of those sales coming from hemp based sources. Projections to date for 2016 indicate the hemp-derived CBD market is poised to grow to $115 million by the end of the year.

The hemp-derived CBD market grew from a market that was barely noticeable a few years ago to $90 million in 2015 for consumer sales of CBD products. Hemp Business Journal shows another $112 million of marijuana-derived CBD products were sold through dispensaries in 2015, for a total CBD market size of $202 million in 2015 across all hemp and legal marijuana markets.

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