CBD or Cannabidiol is one of the primary known cannabinoids found in hemp and cannabis sativa plants. According to numerous clinical studies, CBD offers significant medical benefits without any psychoactive or negative side effects. In fact, CBD actually counteracts the psychoactive effects of the other most common known cannabinoid, delta-9 THC.
Plant derived cannabinoids including CBD interact with receptors or “endocannabinoids” inside the human brain and CNS. According to the US National Institutes of Health, endocannabinoids are “the brain’s own cannabis-like substances which serve as synaptic circuit breakers and regulate multiple physiological and pathological conditions including food intake regulation, immunomodulation, inflammation, analgesia (pain), cancer, addictive behavior, epilepsy and others.”
Cannabidiol molecules can be derived from both industrial hemp plants and cannabis plants. Products made from industrial hemp derived CBD is sold in retail stores, pharmacies and doctors offices in all 50 states, however, CBD from cannabis plants can only be purchased and used under the legal guidelines for use in states where medical or recreational laws have been enacted.
“The ability of extracts of the hemp plant (Cannabis sativa) to cause a variety of medicinal effects unrelated to its psychoactive properties had been recognized as early as the third millennium BC, when Chinese texts described its usefulness in the relief of pain and cramps (Mechoulam, 1986).”U.S. Department Of Health & Human ServicesNational Institutes of Health-National Library of Medicine
“In ancient India, the anxiety-relieving effect of bhang (the Indian term for marijuana ingested as food) had been recorded more than 3000 years ago.”U.S. Department Of Health & Human ServicesNational Institutes of Health-National Library of Medicine
Prior to the outlawing of cannabis in 1937, major pharmaceutical companies produced a wide variety of cannabis-based medicines, but cannabis has actually been used as a medicine for thousands of years. Although it has a long history, the recent discovery (1992) of the body's widespread endocannabinoid system (ECS) has thrust cannabis back into the limelight again as a viable medicine.Steven Leonard-JohnsonRN PhD and author "CBD-Rich Hemp Oil: Cannabis Medicine is Back"
Endocannabinoids are “the brain’s own cannabis-like substances which serve as synaptic circuit breakers and regulate multiple physiological and pathological conditions including food intake regulation, immunomodulation, inflammation, analgesia (pain), cancer, addictive behavior, epilepsy and others.”U.S. Department Of Health & Human ServicesNational Institutes of Health-National Library of Medicine
”The entourage effect is the term used to describe enhancement of efficacy, with related improvement in overall therapeutic effectiveness, derived from combining phytocannabinoids and other plant-derived molecules.”U.S. Department Of Health & Human ServicesNational Institutes of Health-National Library of Medicine
“Putting these pharmacologic, clinical, and societal issues together, the direction for the future resides in the development of orally administered, highly bioavailable, non-psychoactive phytocannabinoid products that also take advantage of the entourage effect, to provide the millions of people living with debilitating pain a comparatively safe and effective form of relief.”U.S. Department Of Health & Human ServicesNational Institutes of Health-National Library of Medicine
Endocannabinoid System (ECS)
Endocannabinoid receptors are the most abundant receptors in the mammalian brain and are also found throughout the peripheral central nervous system (CNS).
According to the US National Institutes of Health, National Library of Medicine, these receptors or “endocannabinoids” are “the brain’s own cannabis-like substances which serve as synaptic circuit breakers and regulate multiple physiological and pathological conditions including food intake regulation, immunomodulation, inflammation, analgesia (pain), cancer, addictive behavior, epilepsy and others.”
Since the relatively recent discovery of endocannabinoids through the study of medical cannabis, the entire natural complex came to be called the “endogenous cannabinoid system,” or “endocannabinoid system” (ECS).
It was discovered that the Hemp Family of plants (cannabis, marijuana) is loaded with cannabinoids that stimulate our ECS receptor sites. These sites are found in the brain, organs, glands, connective tissue and immune cells. The primary purpose of this system revolves around maintaining balance in the body, known as “homeostasis”.
Cannabinoids found in all varieties of cannabis work in harmony with the cannabinoids we naturally produce when our system is functioning properly. It is now coming to light that we may very well be “Endocannabinoid Deficient” and supplementing with Cannabidiol, known as CBD, may provide just what we’re missing to restore optimum health.
Make no mistake about it, the endocannabinoid system, although newly discovered, is just as important as any other bodily system, like the muscular, cardiac, circulatory or digestive system. The ECS requires its own specialized medicine as found in the Hemp Family of plants, which is also known as cannabis, and which includes all strains of marijuana.
The short story? You have an Endo-Cannabinoid System (ECS). It helps regulate many bodily systems. Mother’s milk has endo-cannabinoids and you produce your own, or not. You could be suffering from clinical Endo-Cannabinoid Deficiency Syndrome (CEDS). The Hemp family of plants is the only other source of cannabinoids. One cannabinoid, CBD, just may be the greatest dietary supplement of our lifetime.
We encourage you to do your own research and consult with your physician before taking any new supplements or medication to make sure it is right for you!
Here is a list of conditions known and/or being researched that may be helped by cannabinoid therapeutics and supplementation:
ALS (Lou Gehrig’s Disease)
Prion/Mad Cow Disease
Sickle Cell Anemia
Spinal Cord Injury
Research and studies on CBD and other cannibinoids
Please note: These studies involve CBD and other cannabinoids and are provided solely as an educational resource for those interested in learning more about CBD and its potential wellness benefits in a variety of areas. Our products are not intended to diagnose, treat, cure or prevent any disease.
CBD and Anxiety
2012 – Cannabidiol, a Cannabis sativa constituent, as an anxiolytic drug
2012 – On disruption of Fear Memory by Reconsolidation Blockade: Evidence from Cannabidiol Treatment
2011 – The endocannabinoid system in the regulation of emotions throughout lifespan: a discussion on therapeutic perspectives
2011 – Effects of intracisternal administration of cannabidiol on the cardiovascular and behavioral responses to acute restraint stress
2011 – Cannabidiol potentiates Delta(9)-tetrahydrocannabinol (THC) behavioral effects and alters THC pharmacokinetics during acute and chronic treatment in adolescent rats
2011 – Cannabidiol reduces the anxiety induced by simulated public speaking in treatment-naive social phobia patients
2011 – Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report
2010 – Therapeutical use of the cannabinoids in pyschiatry
2010 – A behavioural comparison of acute and chronic Delta9-tetrahydrocannabinol and cannabidiol in C57BL/6JArc mice
CBD and Inflammation
2012 – Cannabidiol, a non-psychotropic plant-derived cannabinoid, decreases inflammation in a murine model of acute lung injury: Role for the adenosine A(2A) receptor.
2012 – Cannabidiol in Inflammatory Bowel Diseases: A Brief Overview
2010 – Diabetic retinopathy: Role of inflammation and potential therapies for anti-inflammation
CBD and Arthritis
CBD and Pain
2012 – Cannabinoids suppress inflammatory and neuropathic pain by targeting a3 glycine receptors
2010 – Cannabinoid-mediated modulation of neuropathic pain and microglial accumulation in a model of murine type I diabetic peripheral neuropathic pain
2010 – Cannabinoids inhibit and may prevent neuropathic pain in diabetes
CBD and Depression
CBD and Seizures
CBD and Memory
CBD and Brain Damage
2011 – Cannabidiol reduces brain damage and improves functional recovery after acute hypoxia-ischemia in newborn pigs
2010 – Effects of cannabidiol on amphetamine-induced oxidative stress generation in an animal model of mania
2010 – Cannabidiol ameliorates cognitive and motor impairments in bile-duct ligated mice via 5-HT1A receptor activation
2010 – Opposite Effects of Delta9-Tetrahydrocannabinol and Cannabidiol on Human Brain Function and Psychopathology
2010 – Disposition of Cannabichromene, Cannabidiol, and Delta9-Tetrahydrocannabinol and its Metabolites in Mouse Brain following Marijuana Inhalation Determined by High-Performance Liquid Chromatography-Tandem Mass Spectrometry
2010 – Treatment with cannabidiol reverses oxidative stress parameters, cognitive impairment and mortality in rats submitted to sepsis by cecal ligation and puncture
2010 – The neuroprotective effect of cannabidiol in an in vitro model of newborn hypoxic-ischemic brain damage in mice is mediated by CB(2) and adenosine receptors
2010 – Cannabinoid receptor CB1 mediates baseline and activity-induced survival of new neurons in adult hippocampal neurogenesis
CBD and Alzheimer’s Disease & Dementia
2012 – The therapeutic potential of the endocannabinoid system for Alzheimer’s disease
2012 – Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid
2011 – Cannabidiol and other cannabinoids reduce microglial activation in vitro and in vivo: relevance to Alzheimers’ disease
2011 – Memory-rescuing effects of cannabidiol in an animal model of cognitive impairment relevant to neurodegenerative disorders
2011 – Prospects for cannabinoid therapies in basal ganglia disorders
2011 – Phytocannabinoids as novel therapeutic agents in CNS disorders
CBD and Breast Cancer
CBD and Cancer Cells
2012 – Cannabidiol Inhibits Angiogenesis by Multiple Mechanisms
2012 – Poly-e-caprolactone microspheres as a drug delivery system for cannabinoid administration: Development characterization and in vitro evaluation of their antitumoral efficacy
2012 – Cannabidiol-induced apoptosis in murine microglial cells through lipid raft
2011 – Phytocannabinoids for use in the treatment of cancer – Patent GB2478595(A)
2011 – Cannabidiol induced a contrasting pro-apoptotic effect between freshly isolated and precultured human monocytes
2010 – Antitumorigenic Effects of Cannabinoids beyond Apoptosis
2010 – Anti-tumoural effects of cannabinoid combinations – Patent TW201002315 (A)
2010 – Cannabidiol inhibits cancer cell invasion via upregulation of tissue inhibitor of matrix metalloproteinases
2010 – Cannabidiol Enhances the Inhibitory Effects of Delta9 – Tetrahydrocannabinol on Human Glioblastoma Cell Proliferation and Survival
2010 – Cannabidiol attenuates delayed-type hypersensitivity reactions via suppressing T-cell and macrophage reactivity
2010 – Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of efficacy, safety, and tolerability of THC
CBD and Lung Cancer
CBD and Brain Cancer
CBD and Colon Cancer
2012 – Cannabinoids suppress inflammatory and neuropathic pain by targeting a3 glycine receptors
2012 – Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer
2011 – Induction of apoptosis by cannabinoids in prostate and colon cancer cells is phosphatase dependent
2010 – Cannabinoid-mediated modulation of neuropathic pain and microglial accumulation in a model of murine type I diabetic peripheral neuropathic pain.
2010 – Cannabinoids inhibit and may prevent neuropathic pain in diabetes
CBD and Cardiac Arrythmias
CBD and Diabetes
2011 – The potential for clinical use of cannabinoids in treatment of cardiovascular diseases
2010 – Cannabidiol Attenuates Cardiac Dysfunction, Oxidative Stress, Fibrosis, and Inflammatory and Cell Death Signaling Pathways in Diabetic Cardiomyopathy
2010 – Lab Notes: Pot Has Benefits for Diabetic Hearts
CBD and Cholesterol
CBD and Nausea
2011 – Interaction between non-psychotropic cannabinoids in marihuana: effect of cannabigerol (CBG) on the anti-nausea or anti-emetic effects of cannabidiol (CBD) in rats and shrews
2011 – Cannabidiol, a Non-Psychotropic Component of Cannabis, Attenuates Vomiting and Nausea-like Behaviour via Indirect Agonism of 5-HT(1A) Somatodendritic: Autoreceptors in the Dorsal Raphe Nucleus
2011 – Regulation of nausea and vomiting by cannabinoids
2010 – Regulation of nausea and vomiting by cannabinoids
CBD and Appetite
Frequently Asked Questions
Please note: We cannot recommend products for specific conditions. Please consult your primary care physician or wellness practitioner before using cannabidiol to make sure it is right for you.
Some hemp derived CBD products are considered legal in all states. Cannabis derived CBD products are only legal in states with medical or recreational marijuana use. HealthSmart Products are derived from industrial hemp.
No medical card or prescription is needed to buy these products. It is legal to buy CBD made from imported industrial hemp, for use in any state, without a prescription. Individuals ordering CBD products made from medical marijuana plants must live in a state where medical marijuana is legal and have a prescription.
Most drug tests are geared towards identifying THC, not CBD or another cannabinoids. If one uses CBD rich cannabis that has only a small amount of THC, the THC may register on a drug test. A drug test geared toward CBD would not be an effective law enforcement tool, given that CBD is not psychoactive and does not cause impairment.
CBD is a natural occurring substance found in the cannabis plant; a plant that has been known and used by man for over 5,000 years. It has been incorporated into man’s life for so long, the human body even has it’s own endocannabinoid system, (ECS), with receptors found in our nervous system and our immune system to bind with CBD and THC. This is not unlike how we utilize other nutrients we consume to keep our health and wellness optimum. It could be said that CBD might be a dietary supplement we are meant to take regularly like vitamins and minerals. It is a neuroprotectant and an antioxidant, offering preventive qualities, such as vitamin C preventing scurvy. It has been used medicinally all over the world, treating chronic pain, auto immune conditions, cancer cell destruction, and many other ailments. It is even being studied for its effects on epi-genetics as a preventative substance that may help humans avoid such conditions as Alzheimer’s, Muscular Sclerosis, and Senile Dementia. Most importantly, it may the best supplement ever to help the cessation of addictive substances and behaviors such as smoking cigarettes, taking opiates, and alcohol. In the area of psychotherapy, CBD may be the most promising preventative substance in the treatment of PTSD. Based on the definition of a drug above; CBD does not alter the structure of the body, it only optimizes its intended function of that structure, whether it be a neuron or an immune cell in the body. CBD does not alter the function of the body, again it only optimizes it. CBD restores and replenishes, it has no notable physiological changes in a persons vital signs even at very high doses in the range of 1500 mg. It has no apparent toxicity documentations and it appears that the body only absorbs and uses what it needs, just like most vitamins and other nutrients. With the increase in allergies, auto-immune disorders and epidemic PTSD in our world, CBD may be returning to our world just in time, as the most important nutrient we needed and are lacking in, not another drug.
In the last 20 years, natural cannabinoid receptor systems have been discovered in the human body. It is binding to these receptors that cannabinoids produce their pharmacological effects. There are two types of cannabinoid receptors in humans, CB1 & CB2. CB1 receptors are present in the brain, spinal cord and certain peripheral tissues. CB2 receptors are found primarily in immune tissues.
Cannabinoid levels vary. CBD and THC levels, known as cannabinoids vary between plants. Marijuana plants grown for recreational use tend to be high in THC and have varying amounts of CBD. Industrial Hemp, which are to very low in THC, while medical marijuana plants are typically high in CBD.
No. The CBD in our products is a natural, complex element giving you the experience in the best way possible: how nature intended.
Active CBD refers to the complex, full spectrum molecular structure of the CBD molecule, along with the Terbenes, flavonoids, and other cannabinoids that make up the “Entourage Effect”. This maximized, active complex structure provides the most natural, wellness supplement to the body; offering the optimum opportunity for restoration and prevention.